Thursday, April 5, 2018

Autoimmune Disorders that Affect the Blood: Part 3



Today I'm finishing up this series of autoimmune disorders that affect the blood. I hope you have found these three posts informative. Now, let's get going!

Just a reminder: Blood disorders can affect any of the three main components of blood:
  • Red blood cells, which carry oxygen to the body's tissues
  • White blood cells, which fight infections
  • Platelets, which help blood to clot
Blood disorders can also affect the liquid portion of blood, called plasma.

Treatments and prognosis for blood diseases vary, depending on the blood condition and its severity.9 Autoimmune Disorders that Affect the Blood #autoimmunedisorders #autoimmunewellness #blood  


Behcet’s Disease


A rare disorder causing inflammation in blood vessels. Behcet's Disease, also known as Behcet's syndrome, is a rare, chronic, autoimmune, auto-inflammatory disorder of unknown origin. Its manifestations are thought to be caused by vasculitis resulting in damage to blood vessels throughout the body. This disorder is described as a triad of oral ulcers, genital ulcers and ocular inflammation. Read more.

Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)


This is a rare systemic necrotizing vasculitis (this inflammation can interrupt your normal blood flow. It results in skin and muscle damage, including necrosis) that affects small-to-medium-sized vessels and is associated with severe asthma and blood and tissue eosinophilia (Eosinophils are a type of disease-fighting white blood cell.)

The typical patient with EGPA is a middle aged individual with a history of new-onset or newly-worsened asthma. The distribution of the disease among males and females is approximately equal. 

Asthma is one of the cardinal features of EGPA. Asthma symptoms may begin long before the onset of vasculitis – for example, many years before any other symptoms of EGPA arise, and long before the diagnosis of EGPA is made. Other early symptoms/signs include nasal polyps and allergic rhinitis. Read more.

Cold Agglutinin Disease


This is a rare type of autoimmune Hemolytic Anemia in which the body's immune system mistakenly attacks and destroys its own red blood cells. When affected people's blood is exposed to cold temperatures (32º to 50º F), certain proteins that normally attack bacteria IgM antibodies (Immunoglobulin M - IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen.) attach themselves to red blood cells and bind them together into clumps (agglutination). This eventually causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms. Read more.

If you are living with any of these autoimmune disorders that are listed in this post and you would like to comment on them, I would be very interested to hear your point of view. I'm sure readers of this post would be interested as well. 9 Autoimmune Disorders of the Blood #lupus #vasculitis #behcetsdisease Source:
  • https://www.merckmanuals.com/home/blood-disorders/anemia/autoimmune-hemolytic-anemia
  • https://www.nhlbi.nih.gov/health-topics/antiphospholipid-antibody-syndrome
  • https://www.shape.com/lifestyle/mind-and-body/why-autoimmune-diseases-are-rise
  • https://www.nhlbi.nih.gov/health-topics/immune-thrombocytopenia
  • http://www.behcets.com/site/c.8oIJJRPsGcISF/b.9196317/k.904C/Behcets_Disease.htm
  • https://emedicine.medscape.com/article/333492-overview
  • https://www.hopkinsvasculitis.org/types-vasculitis/churgstrauss-syndrome-css/
  • https://rarediseases.info.nih.gov/diseases/6130/cold-agglutinin-disease

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